Born in Shewa, Abebe moved to Addis Ababa around 1952 and joined the 5th Infantry Regiment of the Ethiopian Imperial Guard, an elite infantry division that safeguarded the Emperor of Ethiopia. Enlisting as a soldier before his athletic career, he rose to the rank of shambel (captain). Abebe participated in a total of sixteen marathons. He placed second on his first marathon in Addis Ababa, won twelve other races, and finished fifth in the 1963 Boston Marathon. In July 1967, he sustained the first of several sports-related leg injuries that prevented him from finishing his last two marathons. Abebe was a pioneer in long-distance running. Mamo Wolde, Juma Ikangaa, Tegla Loroupe, Paul Tergat, and Haile Gebrselassie—all recipients of the New York Road Runners’ Abebe Bikila Award—are a few of the athletes who have followed in his footsteps to establish East Africa as a force in long-distance running.
On March 22, 1969, Abebe was paralysed due to a car accident. He regained some upper-body mobility, but he never walked again. While he was receiving medical treatment in England, Abebe competed in archery and table tennis at the 1970 Stoke Mandeville Games in London. Those games were an early predecessor of the Paralympic Games. He competed in both sports at a 1971 competition for the disabled in Norway and won its cross-country sleigh-riding event. Abebe died at age 41 on October 25, 1973, of a cerebral hemorrhage related to his accident four years earlier. He received a state funeral, and Emperor Haile Selassie declared a national day of mourning. Many schools, venues, and events, including Abebe Bikila Stadium in Addis Ababa, are named after him. He is the subject of biographies and films documenting his athletic career, and he is often featured in publications about the marathon and the Olympics.